This article discusses what lies behind the need for utilization of information technologies (IT) and presents examples and analysis of IT utilization that promotes the 3Rs, increases resource efficiency, addresses the labor shortage, and improves the labor environment. The examples of IT utilization for promotion of the 3Rs and increased resource efficiency are discussed from the viewpoint of nine approaches, which include: (1) prevention of product use, (2) sharing of product, (3) reuse of product, (4) long term use of product, (5) reduction of product-use loss, (6) resource saving of product, (7) resource saving of containers and packaging, (8) resource saving in production process, and (9) utilization of secondary resources. Additionally, examples of IT utilization for (10) segregation of waste, and (11) managing the labor shortage and improving labor environments are reviewed. These ideas are, however, only to be thought of as starting points for furthering potential utilization and exploring new business pathways.