Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
A case report of chronic hepatitis B associated with HTLV-I healthy carrier who showed Type I response (Merigan) to Adenine Arabinoside therapy
Hitoshi NAKANO, Michio SATA, Kazuhiko HINO, Hiroshi SUZUKI, Haruo MURAOKA, Yoshihiro ATONO, Katsuyuki ONO, Tatsuya IDE, Ryukichi KUMASHIRO, Hirohiko ABE, Kyuichi TANIKAWA
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Keywords: Adenine-Arabinoside, HTLV-I, seroconversion
JOURNAL FREE ACCESS

1990 Volume 31 Issue 2 Pages 205-210

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Abstract
A case of chronic hepatitis B with HTLV-I healthy carrier which showed Type I response (Merigan) to Adenine Arabinoside (Ara-A) therapy was reported. A 20 year-old-man was diagnosed as chronic active hepatitis by needle liver biopsy. Before Ara-A therapy he was HBV carrier with HBe antigen positive. Just after Ara-A was given, his serum aminotranseferase level began to fluctuate remarkably and was followed by the disappearance of HBeAg and HBsAg 2 months and 5 months later respectably, and appearance of anti-HBs was noted 7 months later. The fact that no familial clustering of HBV but of HTLV-I indicated that he became HBV carrier by horizontal transmisison and HLTV-I carrier by vertical transmission. This is the first report of Type I response induced by Ara-A therapy alone, and is thought to be a valuable case to support the hypothesis that HBV carrier state by horizontal transmissionis terminates more easily than that by vertical transmission.
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© The Japan Society of Hepatology
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