慢性肝疾患におけるc-mycおよびc-Ha-ras発現に関する検討

三田 英治; 林 紀夫; 片山 和宏; 結城 暢一; 竹原 徹郎; 上田 啓次; 古沢 俊一; 佐々木 裕; 笠原 彰紀; 房本 英之; 佐藤 信紘; 鎌田 武信

doi:10.2957/kanzo.31.118

The expression of c-myc and c-Ha-ras products in chronic liver disease

Eiji MITA, Norio HAYASHI, Kazuhiro KATAYAMA, Nobukazu YUKI, Tetsurou TAKEHARA, Keiji UEDA, Syunichi FURUSAWA, Yutaka SASAK, Akinori KASAHARA, Hideyuki FUSAMOTO, Nobuhiro SATO, Takenobu KAMADA

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JOURNAL FREE ACCESS

1990 Volume 31 Issue 2 Pages 118-122

DOI https://doi.org/10.2957/kanzo.31.118

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Abstract

The expression of c-myc and c-Ha-ras products were investigated in chronic liver disease by indirect immunohistochemical method. The c-myc product was observed in 29.8% (14/47) patients with chronic hepatitis and in 27.3% (3/11) patients with liver cirrhosis. The c-Ha-ras product was observed in 19.1% (9/47) patients with chronic hepatitis and in 18.2% (2/11) patients with liver cirrhosis.
Among HBV carriers, the expression of X-protein and HBcAg was observed in successive sections of liver tissues. The c-myc product was more often observed in tissues with X-protein than without X-protein. Also, the c-Ha-ras product was more often observed in liver tissues with X-protein and HBcAg. The positive frequency of HBeAg and the values of DNA polymerase and a-fetoprotein were higher in the c-myc or c-Ha-ras positive patients than in the negative.
These results suggest that the expression of c-myc and c-Ha-ras products may be induced as a signal of liver regeneration after cell damage by the active replication of HBV.

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