Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
Short Communications
Clinical Impact of Increased Sensitivity in the HBV DNA Assay System
Yoshiki Okamoto, Takanori Suzuki, Takako Inoue, Hayato Kawamura, Kentarou Matsuura, Kei Fujiwara, Shunsuke Nojiri, Hiromi Kataoka
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Keywords: HBV DNA
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2025 Volume 66 Issue 7 Pages 290-292

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Abstract

The HBV DNA assay system at our hospital was switched from TaqMan HBV v2.0 to Cobas HBV, increasing the assay's sensitivity from the previous lower limit of quantification of 1.3 logIU/ml to 1.0 logIU/ml. We examined the impact of this change on patients with low HBV DNA levels who were affected by the improved sensitivity. The study included 130 samples with HBV DNA levels below 1.3 logIU/ml. Among these, 19 samples (15%) were quantifiable within the range of 1.0-1.2 logIU/ml using the Cobas HBV DNA assay. This indicates that some cases of HBV DNA can be newly quantified due to the change in the assay system.

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© 2025 The Japan Society of Hepatology
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