Objective: We report the early and long-term results of hybrid endovascular repair of a thoracoabdominal aortic aneurysm (TAAA), perioperative disseminated intravascular coagulation (DIC), and hemorrhagic complications associated with postoperative DIC. Methods: We evaluated 15 patients (10 males and 5 females; median age 74.6 years) who underwent hybrid endovascular repair for TAAA and chronic thoracoabdominal aortic dissection between January 2011 and September 2022. Postoperative complications, survival, incidence of DIC, and risk factors for hemorrhagic complications associated with postoperative DIC were evaluated. DIC was diagnosed using the scoring system established by the Japanese Association for Acute Medicine. Results: Only one patient (6.7%) died within 30 days of treatment due to cerebral hemorrhage. The 5-year survival rate was 64.6% and aneurysm-related deaths were not detected. The 5-year rate of freedom from aneurysm-related complications is 70%. Preoperative DIC occurred in five patients (33%), while postoperative DIC increased in 11 patients (73%), and hemorrhagic complications were detected in 3 patients (20%). A univariate analysis identified preoperative FDP value, thrombus volume, and stent-graft treatment length as risk factors for bleeding complications. Conclusion: Hybrid endovascular repair for TAAA may be a good option for high-risk patients who are ill suited to conventional open repair. Postoperative DIC and hemorrhagic complications associated with extensive stent grafting occur with relatively high frequency and can be fatal. Therefore, risk assessments and appropriate therapeutic interventions for perioperative DIC are necessary.