This paper aims to outline the concept and reality of the research center called Toyohashi Science Core in Toyohashi City. In 1976, the Toyohashi University of Technology was established for the purpose of academic education and promotion of research cooperation between the university and local industry. The university provides a good circumstance for technological research activities and assistance for the industries in the region. In 1990, a joint corporation under the name of Science Create was established, sponsored by both private and public sectors, and the research center, Toyohashi Science Core was built in order to provide a place for high-tech research for the university in cooperation with local industry. Its activities include the training for small local enterprises and cooperative research between industry, the university, and the public sector. Particulary the cooperative research activities are focused on this paper.