Recent studies have focused on investigating factors that moderate the effectiveness of emotion regulation strategies. The purpose of the present study was to examine whether the use of interpersonal emotion regulation strategies moderate the association between cognitive emotion regulation strategies and depression/anxiety. 1,000 participants aged 20 to 69 years, completed self-report measures regarding their daily use of interpersonal and cognitive emotion regulation strategies and depression/anxiety. Results indicated that four of the interpersonal emotion regulation strategies moderate the associations between seven cognitive emotion regulation strategies and depression/anxiety. These findings suggest that the relationship between a particular cognitive emotion regulation strategy and psychological health may depend on individuals’ use of interpersonal emotion regulation strategies. Future studies should examine whether the findings obtained in the present study are replicable.