This study examines how professionals adapt to an institutional change. We focus on the shift of the National Research Institute of Science and Technology from a state-run to an independent administrative agency. The conventional theory is that professionals do not depend on organizations as they have a strong commitment to their occupations. However, we observed a different tendency in an institutional change. The interviews revealed that researchers as well as clerks experienced uneasiness and dissatisfaction. When we analyzed the degree of their uneasiness in relation to the type of work performed and the position held in the organization, it was found that full-time researchers felt the greatest uneasiness with regard to this organizational shift while temporary clerks were anxious about losing their jobs. This paper explains the above phenomenon by using concepts such as "relative deprivation", "the conflict between the old institution and the new institution", and "the dismantling of the researcher's community". The self-subsistence of a person depends on social norms. Therefore, we conclude that increased uneasiness is the result of a perceived decline in a person's superiority. In addition, because each professional works in a specific field, it was difficult for them to unite against the control of the managers and directors. We conclude that this phenomenon is a professional's anomie in a institutional change.