Bolheal interacts with fibrin which forms during the final stage of blood coagulation to cause the tissues to come together and close the wound. It is composed of fibrinogen, blood coagulation fac-torXIII, thrombin, calcium chloride and aprotinin.
Between April 1992 and November 1993, the effectiveness of Bolheal as a tissue glue was studied in 5 cases of extracted supernumerary teeth impacted in the incisal area in children visiting the pedo-dontic department of Aichi-Gakuin university Dental College and Takenoko Dental Clinin. The sub-jects in this study were 4 boys with ages ranging from 5 years and 4 months to 7 years and 4 months, and one girl 6 years and 5 month old.
The results are as follows.
1) Among the 5 subjects, 3 of the boys and one girl had normal eruptive direction and mono cuspid type crown morphology. The other child had eruption in the normal direction with mono cuspid type crown morphology.
2) After removed of the supernumerary teeth, Bolheal was sprayed on the wound of the palatine mucosa using the Bolheal pharmacal instrument set.
3) No symptoms of disconfort were experienced after tooth extraction.
4) Bolheal was found to be effective in stopping bleeding and in stimulating healing of the wound.