Since the guideline has become widely available, the management of childhood asthma has been remarkably improved. But some not-well-controlled cases still remain due to the lack of appropriate treatment of exacerbating factors and comorbidities. This chapter's title has been changed from previously named "Respiratory complications and comorbid conditions of childhood asthma" to "Management of childhood asthma comorbidities" to also encourage the management of any non-respiratory comorbidities. Therefore, we showed the flowchart of the asthma management considering comorbidities, and described obesity and psychosocial factors in addition to allergic rhinitis, sinusitis, and gastroesophageal reflux disease. If the therapy is inadequate, it is important to manage the suspected comorbidities appropriately, with confirming the correct diagnosis and severity of asthma, environment control, and the adherence.