In recent years, children with food allergy not to improve spontaneously increase. These children and their families are forced to great illness burdens in everyday life because they always hold fear and risk for anaphylactogenesis by the false intake in addition to the inconvenience of the elimination diet of the day after day. The establishment of the definitive therapy for food allergy is desired earnestly, and it is a top priority subject in the allergy medical field. Therefore, by utilizing the transcutaneous antigen delivery device (hydrogel patch) brought from our transcutaneous vaccine research, we are attempting to develop the epicutaneous immunotherapy for milk- and chicken egg-allergy and elucidate its response mechanisms. Here, we first give an outline about characteristics and performances of our original hydrogel patch, and then introduce potential and promise of the epicutaneous immunotherapy applied with the hydrogel patch.