A fundamental examination of Flomoxef sodium in the field of oral surgery

SHIGEYUKI TAKATSUKA; MASAHARU NAKAJIMA; MASAHIRO NISHIDE; KEIJI MURAKAMI; SHINYA KOJIMA; TAKASHI NOJIRI; KOICHI OKABE; TOSIHITO BABA; RYUZO KATO; KANYA MATSUBARA; YUICHI NAKAI; TOSHIMI MUROKI; SHIGEHIRO KUMAGAI; EISUKE FUJIMOTO; KIYOMASA NAKAGAWA; ETSUHIDE YAMAMOTO

doi:10.11263/jsotp1982.9.79

SHIGEYUKI TAKATSUKA, MASAHARU NAKAJIMA, MASAHIRO NISHIDE, KEIJI MURAKAMI, SHINYA KOJIMA, TAKASHI NOJIRI, KOICHI OKABE, TOSIHITO BABA, RYUZO KATO, KANYA MATSUBARA, YUICHI NAKAI, TOSHIMI MUROKI, SHIGEHIRO KUMAGAI, EISUKE FUJIMOTO, KIYOMASA NAKAGAWA, ETSUHIDE YAMAMOTO

Author information

SHIGEYUKI TAKATSUKA
Department of Oral Surgery, School of Medicine, Kanazawa University
MASAHARU NAKAJIMA
Department of Oral Surgery, School of Medicine, Kanazawa University
MASAHIRO NISHIDE
Department of Oral Surgery, School of Medicine, Kanazawa University
KEIJI MURAKAMI
Department of Oral Surgery, School of Medicine, Kanazawa University
SHINYA KOJIMA
Department of Oral Surgery, School of Medicine, Kanazawa University
TAKASHI NOJIRI
Department of Oral Surgery, School of Medicine, Kanazawa University
KOICHI OKABE
Department of Oral Surgery, School of Medicine, Kanazawa University
TOSIHITO BABA
Department of Oral Surgery, School of Medicine, Kanazawa University
RYUZO KATO
Department of Oral Surgery, School of Medicine, Kanazawa University
KANYA MATSUBARA
Department of Oral Surgery, School of Medicine, Kanazawa University
YUICHI NAKAI
Department of Oral Surgery, School of Medicine, Kanazawa University
TOSHIMI MUROKI
Department of Oral Surgery, School of Medicine, Kanazawa University
SHIGEHIRO KUMAGAI
Department of Oral Surgery, School of Medicine, Kanazawa University
EISUKE FUJIMOTO
Department of Oral Surgery, School of Medicine, Kanazawa University
KIYOMASA NAKAGAWA
Department of Oral Surgery, School of Medicine, Kanazawa University
ETSUHIDE YAMAMOTO
Department of Oral Surgery, School of Medicine, Kanazawa University

Keywords: Flomoxef sodium (FMOX), Tissue concentration, Minimum inhibitory concentration

JOURNAL FREE ACCESS

1990 Volume 9 Issue 2 Pages 79-84

DOI https://doi.org/10.11263/jsotp1982.9.79

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Abstract

Flomoxef sodium (FMOX) was examined for its fundamental property in tissue concentration and antibacterial potency. The following results were obtained.
1. The tissue concentrations of FMOX after one hour intravenous injection were 14.7±1.8 μg/ml, 8.5±2.1 μg/g and 4.0±3.1 μg/g in serum, gingiva and jaw, respectively.
2. The rates of bacterial disappearance were judged by measuring 75 clinically isolated strains. Eighty percents of minimum inhibitory concentration (MIC₈₀) on 47 strains of aerobic bacteria was 6.3 μg/ml. MIC₈₀ on 28 strains of anaerobic was 1.6 μg/ml.
3. The tissue concentrations measured on serum and gingiva were higher than that of MIC₈₀ clinically isolated 75 strains. From these results, FMOX is considered to be able to prevent bacterial growth in oral infections.

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