ORAL THERAPEUTICS AND PHARMACOLOGY
Online ISSN : 1884-4928
Print ISSN : 0288-1012
ISSN-L : 0288-1012
Therapeutic effects of new anti-inflammatory drug, 2- [4- (2-thiazolyloxy) phenyl] propionic acid (156-S), on postoperative pain after removal of impacted teeth
A double blind controlled study for comparison with indomethacin
HIDETSUGU NISHIKIIRYOSUKE SHIBAHIROAKI TANIOKAYUTAKA HASHIMOTOMASAHITO SUGIMURAKAZUYOSHI UEMURANOBUYA OGAWA
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1987 Volume 6 Issue 1 Pages 8-16

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Abstract
The therapeutic effects of 2- [4- (2-thiazolyloxy) phenyl] propionic acid (156-S) were compared with those of indomethacin (IND) in patients with pain after surgical removal of impacted teeth.
One hundred sixty patients were randomly divided into 2 groups : group I received 300 mg of 156-S and group II received 25 mg of IND, all orally and at the onset of pain.
The clinical effects of each drug were statistically analysed in 130 (63 of group I and 67 of group II) of 160 patients, and the following results were obtained:
1) The analgesic effect appeared in a significantly shorter time in group I than in group II.
2) The analgesic effect one hour after the administration of the drugs was significantly greater in group I than in group II.
3) The analgesic effect lasted considerably longer in group II than in group I.
4) No specific adverse reactions were detected with the drugs.
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