口腔癌に対するネオアジュバント化学療法の有用性 1.2経路注入法を組み入れたシスプラチン-ビンブラスチン-ペプロマイシン併用療法 (CVP療法) の直接効果と予後に及ぼす影響

和田 健; 畠 祥子; 森田 展雄; 大亦 哲司; 井辺 弘樹; 岡本 圭一郎; 松平 淳; 武用 由加; 神木 茂樹; 宮田 和幸; 坂本 忠幸; 川島 稔弘; 湯浅 祥司; 原田 昌和; 坂上 卓也; 寒川 俊子

doi:10.5843/jsot.8.8

Significance of combined neoadjuvant chemotherapy on oral cancer

1. The clinical effects of cisplatin-vinblastine-peplomycin (CVP) combination chemotherapy included in two route administration and its prognostic significance

Takeshi Wada, Sachiko Hata, Nobuo Morita, Tetsuji Oomata, Hiroki Inbe, Keiichirou Okamoto, Jun Matsuhira, Yuka Buyo, Shigeki Shinnoki, Kazuyuki Miyata, Tadayuki Sakamoto, Toshihiro Kawashima, Syoji Yuasa, Masakazu Harada, Takuya Sakagami, Toshiko Samukawa

Author information

Takeshi Wada
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Sachiko Hata
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Nobuo Morita
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Tetsuji Oomata
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Hiroki Inbe
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Keiichirou Okamoto
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Jun Matsuhira
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Yuka Buyo
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Shigeki Shinnoki
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Kazuyuki Miyata
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Tadayuki Sakamoto
Department of Oral and Maxillofacial Surgery, Wakayama Medical College
Toshihiro Kawashima
Division of Oral and Maxillofacial Surgery, Hashimoto Municipal Hospital
Syoji Yuasa
Division of Oral and Maxillofacial Surgery, Hashimoto Municipal Hospital
Masakazu Harada
Division of Oral and Maxillofacial Surgery, Kinan General Hospital
Takuya Sakagami
Division of Oral and Maxillofacial Surgery, Kinan General Hospital
Toshiko Samukawa
Division of Oral and Maxillofacial Surgery, Kinan General Hospital

Keywords: two route infusion, CDDP-VLB-PEP (CVP) combination chemotherapy, clinical effects, prognosis

JOURNAL FREE ACCESS

1996 Volume 8 Issue 1 Pages 8-15

DOI https://doi.org/10.5843/jsot.8.8

Details

Abstract

The therapeutic effects of neo-adjuvant chemotherapy administered by two route infusion of cisplatin and its antidote, sodium thiosulfate, and intravenous infusion of vinblastine and peplomycin were studied on 35 patients with previously untreated squamous cell carcinoma of the oral cavity, maxillary sinus, or oropharynx. The overall response rate to chemotherapy was 91.4%, and complete response rate was 57.1%. When the patients who died of a disease other than tumor were excluded, the cumulative 5-year survival rate was 100% in CR and 87.5% in PR plus NC. This chemotherapy could be carried out in a shorter time period because of the appropriate supporting therapy. Twelve out of 20 CR patients underwent conservative surgery, and they are all free from tumor and have good oral function. These data showed that this chemotherapy may be more effective for treatment of head and neck cancer. The results are preliminary, and additional studies using more patients are needed.

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