Oral exfoliative cytology is a very effective screening method because of its small surgical damage, low cost, and repeatable exfoliation. About 8, 800 cases of oral cytological specimens have been experienced since 1988 in the Department of Oral Pathology, Nihon University School of Dentistry at Matsudo. All of the cytological specimens were analyzed statistically. The details and accuracy rate are reported here. The accuracy rate of malignancy (Class V ) was 93.5% and the method showed high suitability for assisting examination of oral cancer. Important factors of false-positive cases were Candida infection, whitish patch and ulcer formation, and that of false-negative cases was whitish protrusions identified macroscopically. We expect an increasing number of private dental clinicians will use oral exfoliative cytology for the examination of oral cancer. Observation of macroscopic findings as mentioned above and sufficient cell collection are key points.