Super-selective intra-arterial infusion chemotherapy using cisplatinum (CDDP) has been an established organ-preserving therapy for squamous cell carcinoma of the head and neck region. We have observed a constant treatment response in advanced cases by combined intra-arterial and systemic chemotherapy. Our protocol consisted of intra-arterial infusion of docetaxel (DOC) by the Seldinger method on day 1 followed by intra-venous instillation of CDDP for one day, and continuous infusion of 5-fluorouracil (5-FU) for 5 days from day 2. Radiotherapy was administered from day one until the total dose exceeded 60 Gy. The three-years overall survival rate of stage III–IV disease was 69%. As for adverse reactions in grade 3–4 diseases, leukopenia was noted in 70% and mucositis in 47%. For intra-arterial infusion chemotherapy, detailed anatomical knowledge and identification of a feeding artery are necessary to eradicate the tumor with no neurological events. To clarify the role of the intra-arterial infusion chemotherapy in the treatment system, multi-institutional clinical trials are now being planned.