Poly(ethylene terephthalate) sheet coated with a double layer of gelatin and readily soluble calcium phosphate (CaP) has been proposed as a non-resorbable membrane in guided bone regeneration(GBR). This material promoted the proliferation and differentiation of MC3T3-E1 cells in vitro, which was attributed to the readily soluble nature of the CaP layer providing Ca^2＋ ions to the MC3T3-E1 cells. On the other hand, the migration of endothelial cells is also known to be promoted by Ca^2＋ ion supply, which implies that the material may also promote the migration of endothelial cells. The present study investigated the effect of the CaP layer on the migration and extension of human umbilical vein endothelial cells (HUVEC), which are responsible for angiogenesis. The experimental results showed that the CaP layer significantly promoted the migration and extension of HUVEC cells.