Clinical medicine with genomic science is defined as clinical application of genomic findings. Translational research (TR) is required to narrow the gap between clinical medicine and genomic findings. There are multi-disciplinary approaches to understanding the complex biology of whole organisms in their natural environments. These approaches rely on knowledge covered by conventional analytical techniques of life science and by bioinformatics and computer science. Sharing the whole knowledge is essential for the multi-disciplinary approaches. The purpose of TR is also testing to apply novel therapeutic strategies to humans, which are developed through experimentation. The ethics is indispensable to the operation of TR. We propose to develop research environment, that is, an intelligent information system to support TR. In this paper, a system concept of the intelligent information system is discussed in the view of the logic and the ethics.