We investigated emotional and mood variations between two different groups of the nurses in our hospital in June, September, and December of the graduate year and compared them with a control. The profile of mood status (POMS) test was applied to the nurses who were assigned to the intensive care unit (ICU group) and those who were assigned to the general wards (Ward group). A group of healthy female volunteers aged from twenty to twenty-nine were also examined as a control. The ICU group always demonstrated a higher score in “Tension-Anxiety” cathegory than the control group and the Ward group constantly showed higher scores in “Fatigue” and “Confusion” categories than the control. We conclude that newly registered nurses who were assigned to general wards demonstrated more exhaustion than those who were assigned to ICU did.