We report a case of reversible myocardial injury and cardiogenic pulmonary edema after ingestion of phenylpropanolamine. The patient is a 19 year old Japanese female without a remarkable past history and family history, whose chief complaint is vomiting two hours after ingestion of 544mg of phenylpropanolamine. Myocardial injury and cardiogenic pulmonary edema were diagnosed by electrocardiogram, chest X-ray, creatine kinase level, echocardiogram, ¹²³I-MIBG scintigraphy and Swan-Ganz profiles. Catecholamine, phosphodiesterase inhibitor, and diuretics were the treatment of choice. The patient was discharged on day 12 without any sequelae. We reviewed nine reported cases of myocardial injury associated with phenylpropanolamine including our case from the literature. Utilizing the similarity of anatomical pattern of reversible myocardial injury, we hypothesized that myocardial injury associated with phenylpropanolamine of this case can be a variant of ampulla cardiomyopathy.