In the 1950’s, perioperative mortality rates ranging from 20 to 45% used to be reported for pheochromocytomas. However, since usage of α1-blockers perioperative mortality rate dropped to 3 to 4% in 1970’s. Also, important developments which have contributed to this major reduction in perioperative mortality rate are better imaging techniques for accurate preoperative tumour localization. It is important for physicians, surgeons and anesthesiologists to cooperate closely. Laparoscopic adrenalectomy has become the gold standard for removing adrenal masses because of their minimal invasiveness. Pheochromocytomas are no exceptions, and many reports say laparoscopic surgery is minimally invasive and safe to treat tumors smaller than 6cm in diameter. Hereditary pheochromocytomas show different frequencies of becoming malignant or multiple depending on each respective hereditary syndrome. Therefore, treatments for these would vary accordingly. Pheochromocytomas such as MEM2, VHL, and PGL1 are frequently multiple and rarely malignant. It is necessary to try to maintain adrenal function, and be careful to avoid lifelong corticosteroid replacement and acute adrenal insufficiency.