A 69-year-old woman consulted our hospital in April 1991. She had chronic hepatitis, cardiomegaly and chronic renal failure. In December 1992, a small subcutaneous nodule appeared on her right upper arm. In June 1993, hemodialysis therapy was started. The painful skin ulcer on her right arm developed over subcutaneous calcified plaques (tumoral calcinosis), and similar lesion later appeared on the left upper arm. In September 1994, she experienced severe sinus dysfunction and an artificial pacemaker was implanted. She was admitted to our hospital in September 1997 because of lumbago and anorexia. Both upper arms were deformed by tumoral calcinosis shown by roentgenogram and a pigmented skin ulcer was present on the right arm. The analysis of calcified tissue revealed 51% of calcium phosphate and 49% calcium carbonate. The skin biopsy specimen showed many inflammatory cell infiltrations around small vessels, marked increase of fibrous tissue and scattered calcification without fatty tissue inflammation. Laboratory data showed increased i-PTH and Ca×P product. Increased subcutaneous calcification was likely to have occurred simultaneously with increasing i-PTH and Ca×P levels. She was diagnosed with hepatoma in November 1999 and she died in May 2000. Autopsy was done and calcified amorphous tumor was found adjacent to the mitral valve. On analysis, the calcified amorphous tumor was 67% calcium phosphate and 33% calcium carbonate. We reported here rare case f a hemodialysis patient with tumoral calcinosis of the proximal extremities along with cardiac calcified amorphous tumor.