A 61-year-old woman was transferred to our hospital with nausea, tense abdominal distension, and upper abdominal pain. She exhibited bilateral cyanosis and livedo reticularis of both lower extremities. Contrast-enhanced computed tomography revealed that the markedly expanded stomach compressed the abdominal aorta, resulting in a lack of contrast enhancement of the aorta distal to the renal arteries. We diagnosed the patient with gastric volvulus causing abdominal aortic compression, and inserted a stomach tube in order to decompress the stomach. Although the cyanosis and livedo reticularis immediately resolved, she developed hypotension and disturbance of consciousness and required mechanical ventilation. She showed port-wine-colored urine, and arterial blood gas analysis showed lactic acidosis and hyperkalemia. We diagnosed her with myonephropathic metabolic syndrome (MNMS) caused by ischemia-reperfusion injury resulting from the release of aortic compression following gastric decompression, and urgently initiated blood purification therapy. For the ischemic stomach, total gastrectomy was performed after her general condition improved. We discontinued renal replacement therapy about one month later, as her kidney function recovered. In cases of MNMS with extensive ischemia-reperfusion, it is necessary to consider urgent blood purification therapy.