As a shortage of kidney donor exists, there is a trend toward an increase in ABO-incompatible kidney transplants in Japan. The removal of anti-A anti-B anti-blood type antibody is primarily necessary for ABO-incompatible kidney transplants, and double filtration plasmapheresis (DFPP) is usually performed before transplant. DFPP contains various albumin concentrations as replacement fluid: 7.5%, 1,500 mL; 8.3%, 1,800 mL; 9.0%, 2,500 mL; and 10%, 2,000 mL. The rates of change for antibody titers and procedure side effects were analyzed. In the results of this study, a lower concentration of albumin tended to be associated with nausea, vomiting and a lower blood pressure. All patients underwent kidney transplantation successfully, and titer reduction did not differ in the groups. In order to avoid the procedural side effects and reduce the appropriate antibodies titer, a higher albumin (9.0～10.0%) concentration should be encouraged before ABO-incompatible kidney transplants.