In the 2016 Kumamoto earthquake, the bridge-pipeline-ground coupled systems had a great deal of substantial damage, and the damage mechanism of these coupled responses are required to be clarified. The characteristics of the coupled responses of the system were clarified when the strong motions equivalent to the main earthquake acted on a typical bridge-pipeline-ground coupled system located in Mashiki Town. The results revealed the following: 1) the response of the pipeline is suppressed at the center span of the bridge, but increases near the abutments and pier; 2) the generation of axial stress in the bridge axis direction due to different coupled vibrations between the abutment backfill, bridge girder, abutment and pier may contribute to the damage of the pipeline near the abutments; and 3) the response of the pipeline near the pier increases due to the relatively larger vibration of the bridge girders than that of the pier and pile foundation.