In order to investigate the responses of a vehicle under strong cross-wind, numerical simulations and driving simulator experiments were conducted. The responses of a vehicle under cross-wind were simulated using a numerical model, which can consider the interaction between the reaction of a driver and the motion of the vehicle. The simulated results showed good agreements with those obtained from the driving simulator experiments. Hence, the responses of a vehicle under cross-wind can be simulated systematically using the numerical model if the parameters for different vehicles are properly determined.