An innovative continuous PC girder with large eccentric external tendons was developed for bridge structures. Experimental and analytical investigations were carried out on the flexural behavior of such girders in order to identify the design considerations of such girders. It was found that the structural performance of PC girders with large eccentric external tendons is improved compared with the conventional use of external tendons, by effective use of materials. In addition, considerable flexibility can be achieved in the design of cable layout to suite various site conditions. Further, the analytical methodology developed for external tendons can be extended for these girders as well.