発育期環境要因による神経精神疾患発症の制御

田熊 一敞; 吾郷 由希夫; 原 雄大; 長谷部 茂; 中澤 敬信; 橋本 均; 松田 敏夫

doi:10.11249/jsbpjjpp.28.1_22

Regulation of neuropsychiatric and neurodevelopmental disorders by juvenile environmental factors

Kazuhiro Takuma, Yukio Ago, Yuta Hara, Shigeru Hasebe, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda

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Keywords: neuropsychiatric disorders, neurodevelopmental disorders, PACAP, valproic acid, environmental enrichment, dendritic spines

JOURNAL OPEN ACCESS

2017 Volume 28 Issue 1 Pages 22-26

DOI https://doi.org/10.11249/jsbpjjpp.28.1_22

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Abstract

Many clinical and epidemiological researches have pointed out the importance of environmental factors, as well as genetic factors, in the etiology of psychiatric and neurodevelopmental disorders. Then, in late years, there is a growing number of animal studies focused on the environmental etiology of psychiatric illness. We have recently investigated the roles of juvenile environmental factors in the psycho-neurologic functions and the effects of maternal environment in the pre-and perinatal periods on the neurodevelopment of offspring. In this review, we summarize our findings on the improvement of psychobehavioral and neuroanatomical abnormalities by environmental factors and drug treatments during juvenile periods in the PACAP-KO mice, a schizophrenia animal model, and the prenatal valproate-exposed mice, an autism animal model, and further discuss the possibility of environmental regulation in the pathogenesis of psychiatric and neurodevelopmental disorders.

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