If patients understand their illness and treatment, because of understanding of therapeutic goal of medical staff, treatment becomes more effective and smooth. In treatment of major depressive disorder, it is necessary to build a positive therapeutic relationship first, and inform patients about the nature of depressive disorder and its treatment to encourage patients’ compliance. After the information about depressive disorder is given, it is important to provide convincing disease models for patients and cultivate a shared understanding of treatment. We have conduct a cohort study on pregnant and parturient women and confirm several findings. Specifically, as a result of the depressive state: 1. Negative recognition like a Harm Avoidance appears (disappears by treatment) , 2. Recognition of a nurtured experience changes (They recognize that their mothers were overprotective) , 3. Bonding to a child falls. In this review, we discuss how explain about depressive disorder based on our study outcomes.