One of the hypothesis of pathophysiology of psychiatric disorder is that it is caused by reduced neuronal plasticity including synaptic formation and adult neurogenesis dysfunction. This symposium will provide a platform to bring together various experts in the field of brain cytokine/hormone, and epigenetic and imaging studies in alcohol - induced brain damage and affective disorders to give comprehensive idea for progress in this field and produce possible new therapeutic peripheral- derived markers for its pathophysiological understanding and diagnosis.