The Nagahama Study is a community - based long - term prospective cohort study co - organized by Kyoto University Graduate School of Medicine, Nagahama City in Shiga Prefecture and Zeroji Club, an NPO founded by citizens of Nagahama. The study was designed as a model case for the comprehensive understanding of health and disease in humans, through integrated analyses using information gathered from multiple omics studies in combination with life style and environment. It also aims to establish futuristic health promotion and the basis of personalized health care and disease treatment. More than ten clinical departments are involved in the project with a variety of target diseases such as COPD and asthma, cardiovascular diseases, ophthalmic diseases and periodontal diseases. The baseline study started in 2007, and a total of 115 biochemical and hematological traits have been measured from blood and urine samples. Self - administered questionnaire consisting of 742 questions were used to collect life style and environmental exposures as well as potential disease threats. The enrollment of 10,082 healthy residents was successfully finished in 2010. Genome- wide association study using SNP arrays was initiated in 2009 and, to date, approximately 4,000 DNA samples have been genome scanned and subjected to association analyses. Whole metabolome analysis is under way with GC- Mass spectrometry in collaboration with Shimazdu, a world- leading company of Mass spectrometry technology. A follow- up study planned every five years after the baseline survey will start this autumn to further accumulate health- related information and biological materials.