This paper proposes a new approach integrating the modeling of moving persons from sensor data and agent-based simulation for indoor layout design. First, we applied this framework to the prevention of children's accidents. Our model focuses on interaction between indoor objects and children to estimate the risk of indoor accidents. Next, it was used for workflow analysis and layout design in an operation room. Finally, We discuss the agent-based simulation of multiple persons moving in public spaces and its application to evaluating information presentation for guidance.