Anionic Sweet Tasting Derivatives of the Anti-Inflammatory Drug β-Glycyrrhetinic Acid

Toshinobu TOYOSHIMA; Seizo TAMAGAKI

doi:10.5650/jos1996.49.1407

Journal of Japan Oil Chemists' Society

Online ISSN : 1884-1996
Print ISSN : 1341-8327
ISSN-L : 1341-8327

Anionic Sweet Tasting Derivatives of the Anti-Inflammatory Drug β-Glycyrrhetinic Acid

Toshinobu TOYOSHIMA, Seizo TAMAGAKI

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Keywords: β-glycyrrhetinic acid, anionic derivatives, sulfates, sweet taste, sweetness mechanism

JOURNAL FREE ACCESS

2000 Volume 49 Issue 11-12 Pages 1407-1412,1447

DOI https://doi.org/10.5650/jos1996.49.1407

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Abstract

Anionic derivatives of β-glycyrrhetinic acid (GA) were prepared and assessed for sweetness. It was found that the presence of both a carboxyl group (COOH, free form) at C20 position and a carboxylate moiety (COO^-) at C3 position in the GA molecule is essential for sweet taste. A plausible mechanism for sweet taste is proposed.

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