This short paper presents a humanities-oriented natural disaster studies perspective on the novel COVID-19 pandemic now sweeping the entire world, including Japan. Borderless nature of this pandemic has destructive potential on the following three fundamental theoretical assumptions in conventional humanities-oriented natural disaster science. First, disaster management can be planned and implemented spatially, reflected in a designation of“flood inundation area,”for example, which is a“zoning”assumption. Secondly, disaster management can be planned and implemented based on a temporal phase thinking, shown in a well-known“disaster management cycle,”which is a“phasing”assumption. Finally, disaster management can be planned and implemented in a role-positioning structure of a disaster experts vs. non-experts, which is a“positioning”assumption. It is also discussed how we can reconsider these three basic assumptions,“zoning,”“phasing,”and“positioning,”to develop natural disaster science further.