A new technique for preparation of molybdenum single crystal with a desired orientation has been proposed. The technique was performed as follows; first, a specimen with a comb shape was mechanically fabricated from hot-rolled sheet with various rolling procedures and reductions. Then the edge of specimen with a comb shape was locally heated by the optical-beam image furnace in order to make some secondary recrystallized grains with various orientations. After the secondary recrystallized grains were mechanically eliminated except for a secondary grain having a desired orientation, the specimen was zone-annealed at 2000-2200°C at the zone-speed of 5 mm/ hr to grow the secondary grain. Consequently, molybdenum single crystal with a desired crystallographic orientation can easily be produced.