Purpose: The mechanism of the effect of polarized infrared ray irradiation near the stellate ganglion (PIRISG) is unknown. The purpose of this study is to analyze peripheral sympathetic activity during PIRISG by quantitative measurment of perspiration and skin temperature. Methods: Irradiation was performed near the stellate ganglion of ten healthy adults for 20min using 80% maximum power output of 1, 800mW with cycles of 1 second on and 2 seconds off. The perspiration volume was measured for three minutes and was compared before irradiation, at 10 minutes, and at 20 minutes of irradiation. The skin temperature was recorded at one-minute intevals. Results: The baseline volume of perspiration was 1.000±0.202mg·3min^-1, at 10min of PIR irradiation was 0.931±0.238mg·3min^-1, and at 20min of PIR irradiation was 0.953±0.289mg·3min^-1. There were no significant differences in perspiration volume among control, at 10 and 20min of PIR irradiation. Skin temperature did not change during the study period. Conclusion: PIRISG does not show any inhibitory activity on peripheral sympathetic nerve activity in healthy adults during irradiation.