A case of SLE with leg pain was managed by Neurolytic Lumbar Sympathetic Ganglion Block (NLSGB). The intensity of leg pain decreased by half. A 42-year-old woman diagnosed with SLE and hospitalized for over 20 years had muscle weakness, atrophy and sensory disturbance in her legs. The patient complained of pain and dysesthesia of the extremities, which could not be controlled by administering NSAIDs. The patient was referred to our hospital with epidural catheter in place for 2 months. Epidural analgesia with one dose of 1% mepivacaine reduced leg pain for 2 hours; then the legs became warm but more numb. As bathing and keeping feet warm reduced pain, we performed NLSGB bilaterally to increase skin temperature of the feet. The day following NLSGB, her leg pain decreased by half that before admission to our hospital. The skin temperature of the right toes rose from 29.5°C to 34°C. The pain was controllable without epidural analgesia.