Intractable hiccups are a relatively uncommon condition characterized by involuntary, spasmodic contractions of the diaphragm that may last for more than 48 hours or even more than 2 months. We reviewed the medical records of 8 patients with intractable hiccup who were introduced to our pain clinic. Phrenic nerve block and baclofen were effective in 6 patients, but ineffective in the other 2. Our cases showed that that the combination of baclofen and phrenic nerve block could significantly improve the quality of life for a patient with intractable hiccups.