Journal of Japan Society of Pain Clinicians
Online ISSN : 1884-1791
Print ISSN : 1340-4903
ISSN-L : 1340-4903
The effect of increase in quantity of tricyclic antidepressant for non acute zoster-associated pain (more than 30 days after the onset of herpes zoster)
Kazuhiko HIRATAKazuo HIGAKazunori HIROTAKouhei IWASHITAKeiko SAKIMURAMayumi IKEDAYutaka KENMIZAKIShiho SHIBATA
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2012 Volume 19 Issue 4 Pages 482-489

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Abstract
We retrospectively studied doses of tricyclic antidepressants (TCAs) for the treatment of non acute zoster-associated pain (more than 30 days after the onset of herpes zoster [ZAP]) in 58 patients who visited our department. TCAs had been taken in 26% of the patients, and anticonvulsants in 5%. We prescribed TCA, either amitriptyline or nortriptyline, to 88% of the patients, and anticonvulsants, either gabapentin or valproic acid, to 58%. Initial median daily dose of amitriptyline was 10.0 mg, which after 4 weeks was gradually increased to 50.0 mg (quartile range 22.5-93.8 mg). Mean pain decreased from 66.5 mm to 23.2 mm on a 100-mm visual analog scale (VAS). The initial median daily dose of nortriptyline was 10.0 mg, which after 4 weeks was gradually increased to 30.0 mg (21.5-50.0 mg). Pain decreased from 60.6 mm to 27.9 mm on VAS after 4 weeks. TCAs reduced non acute ZAP. The doses of TCA to control non-acute ZAP varied from patient to patient greatly.
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© 2012 Japan Society of Pain Clinicians
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