We report a rare case of tongue ulceration caused by cytomegalovirus （CMV） infection, together with a review of the Japanese literature. The patient was an 82-year-old woman who was receiving treatment for rheumatoid arthritis and consulted our hospital with a chief complaint of tongue ulcer. By biopsy, the lesion was diagnosed as an ulcer caused by CMV infection, however, improvement was observed during follow-up observation.
In Japan, only nine cases of oral CMV infection have been reported including the present case, and tongue ulcer was the most common.