抜歯後出血を契機に発見された多凝固因子活性低下をともなった後天性血友病の1例

鵜澤 一弘; 坂本 洋右; 小山 知芳; 神津 由直; 小池 博文; 笠松 厚志; 小河原 克訓; 椎葉 正史; 丹沢 秀樹

doi:10.6014/jjsom.18.63

Case Reports

A Case of Acquired Hemophilia with Significant Reduced Activities in Multiple Coagulation Factors Diagnosed by Severe Postoperative Bleeding of Tooth Extraction

Katsuhiro UZAWA, Yosuke SAKAMOTO, Tomoyoshi KOYAMA, Yokinao KOUZU, Hirofumi KOIKE, Atsushi KASAMATSU, Katsunori OGAWARA, Masashi SHIIBA, Hideki TANZAWA

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Keywords: acquired hemophilia, factor VIII inhibitor, hemorrhage after tooth extraction

JOURNAL FREE ACCESS

2012 Volume 18 Issue 2 Pages 63-67

DOI https://doi.org/10.6014/jjsom.18.63

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Abstract

Acquired hemophilia is a rare bleeding disorder characterized by the presence of autoantibodies directed factor VIII inhibitor (FVIII). We here describe the case of a 69-year-old Japanese woman who presented with severe bleeding after tooth extraction and found to have acquired hemophilia with reduction of the activity for multiple coagulation factors. Hemostasis was achieved after treatment with hemodynamic stabilizsation and immunosuppression therapies. Although we are not able to confirm the absence of FVIII inhibitor even after 11 years post diagnosis, there is no evidence of re-hemorrhage under the supervision of a specialist in hematology.

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