NEC成分と腺癌成分が非典型的な分布を呈した肛門管MiNENの1例

吉田 昂平; 豊福 篤志; 伊藤 一馬; 櫻井 晶子; 日暮 愛一郎; 四元 真司; 笹栗 毅和; 永田 直幹

doi:10.3919/jjsa.83.557

Case Reports

A Case of Anal Canal Mixed Neuroendocrine-non-neuroendocrine Neoplasm with an Atypical Distribution of Neuroendocrine Carcinoma and Adenocarcinoma Components

Kohei YOSHIDA, Atsushi TOYOFUKU, Kazuma ITO, Akiko SAKURAI, Aiichiro HIGURE, Shinji YOTSUMOTO, Takakazu SASAGURI, Naoki NAGATA

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Keywords: mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN), mixed adenoneuroendocrine carcinoma (MANEC), anal canal

JOURNAL FREE ACCESS

2022 Volume 83 Issue 3 Pages 557-565

DOI https://doi.org/10.3919/jjsa.83.557

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Abstract

An 89-year-old woman developed anal pain in November 2020 and visited a nearby clinic. She was then referred to our hospital in December on suspicion of anal canal cancer. Colonoscopy showed a neoplastic lesion in the anal canal, with neuroendocrine carcinoma on biopsy examination, with atypical ductal epithelial areas in some areas. No distant metastasis was found, and robot-assisted laparoscopic abdomino-perineal resection of the rectum and anal canal + lymph node dissection was performed in January of the following year. The resected specimen showed the pathological findings of neuroendocrine carcinoma in the superficial part of the lesion and adenocarcinoma in its deep part. These findings were rare compared with the cases previously reported. The diagnosis was mixed neuroendocrine-non-neuroendocrine neoplasm, Stage IIA, according to the UICC TNM Classification System (8th Edition). The patient's postoperative course was uneventful, and she was discharged 27 days after the operation.

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