A 65-year-old man who was diagnosed with rectal cancer underwent laparoscopic assisted low anterior resection with D3 lymph node dissection (well differentiated adenocarcinoma, ss, n0). After the surgery, he received transverse colostomy because of anastomotic leak with generalized peritonitis. Five months later, CT showed a 25-mm tumor at S5 of the liver. He was referred to our hospital with a diagnosis of liver metastasis of the rectal cancer. He underwent subsegmentectomy of the liver and closure of the colostomy. The resected specimen included a 19 × 18 mm well-circumscribed solid tumor with no malignant findings. The tumor was composed of many formations of granuloma with central necrosis. Grocott staining confirmed small spherical structures of fungal spore. These findings were consistent with a diagnosis of inflammatory granuloma of fungi. It seems that generalized peritonitis induced by anastomotic leak might cause this tumor, because no liver tumor was present at the initial operation. We report the clinical course of inflammatory granuloma in this case with bibliographic consideration.