A 40-year-old woman had a positive fecal occult blood test. On colonoscopy, an ulcer was found in the ascending colon. On examination of the biopsy, Mycobacterium tuberculosis was identified. Tuberculosis was thus diagnosed. Anti-tuberculosis agents such as pyrazinamide, isoniazid, rifanmpicin, and ethambutol were given. During therapy, she developed right abdominal pain. Abdominal CT showed a thickened and enlarged ascending colon. It was proposed that the drugs had caused stenosis of the colon by constricting the lesion. A laparoscopic right hemicolectomy was performed. On pathology, fibrosis granulation tissue but no granulomatous lesion was found, thus confirming that the stenosis was caused by the constriction of the intestine related to anti-tuberculosis drug therapy. The patient's post-operative course was good ; the drugs were stopped. In summary, during treatment of tuberculosis, ileus caused by intestinal tuberculosis may occur. In this situation, a laparoscopic approach should be considered.