A patient, 72-year-old male, saw his private physician with the chief complaint of generalized malaise and loss of appetite of two months duration. The patient was referred to our hospital with diagnosis of a hepatic tumor and was admitted for further studies and possible treatment. Abdominal CT and echo study revealed a tumor of about 4cm in diameter size in S6 of the liver and a metastatic cancer or biliary cell carcinoma was suspected. Mesenteric arteriogram did not indicate the presence of hepatocellular carcinoma. A definite diagnosis was not able to be made by the image studies even though some type of malignant hepatic tumor was suspected. Echo guided needle biopsy of the liver was performed and it revealed a pathology of inflammatory cellular infiltration and proliferation of connective tissue, leading to the diagnosis of inflammatory pseudo-neoplasm. Fever and pain in the right hypochondrium followed that did not respond to a conservative treatment, therefore a partial hepatectomy was performed. Pathological diagnosis of the resected specimen coincided with the finding of the needle biopsy. Hepatic inflammatory pseudo-neoplasm is relatively a rare entity and to make diagnosis is often difficult. We experienced a rare case of hepatic inflammatory pseudo-neoplasm with difficult differential diagnosis from a malignant tumor and was finally diagnosed by a needle biopsy. We report the case here with some review of the literatures.