The Japanese Pharmacopoeia defines the original plants of the crude drug Akebiae Caulis (Mutong in Chinese) as Akebia quinata (Houtt.) Decne. and A. trifoliata (Thunb.) Koidz.　However, in China, the original plants of Mutong vary greatly and include Clematidis Armandii Caulis (Chuan-Mutong in Chinese) derived from Ranunculaceae and Aristolochiae Manshuriensis Caulis (Guan-Mutong in Chinese) derived from Aristolochiaceae. We have reported that Akebia plants are the authentic original plants from ancient times, but it was not clear how Mutong derived from other plants has come into use.　In this paper, we investigated the historical changes in the use of Mutong derived from Lardizabalaceae, Vitaceae, GuanMutong, and Chuan-Mutong. We found that the product derived from Akebia plants, which had been the authentic Mutong, was replaced by Chuan-Mutong in the late Qing dynasty.　Mutong derived from Vitaceae was used as a substitute for Akebia plants between the Song and the early Qing dynasties.　We also found that GuanMutong, a crude drug characterized by bitterness, came into use from the early Qing dynasty and replaced Mutong derived from Vitaceae.