There are few reported cases of head and neck cancer occurring during pregnancy. In such cases, the safety of the mother and fetus is the top priority in making decisions about treatment. In our department, we have treated four patients who developed head and neck cancer during pregnancy. Three of the patients underwent surgical treatment during pregnancy and had a successful delivery. The remaining one patient received surgical treatment after artificial termination of pregnancy. When treating head and neck cancer patients with pregnancy, it is essential to provide an individualized treatment course, as well as sufficient relevant information for the patients and their families.