セツキシマブ併用放射線療法を施行した下咽頭癌症例に対する経口的救済手術の検討

野村 文敬; 杉本 太郎; 川田 研郎; 角 卓郎; 有泉 陽介; 清川 佑介; 田崎 彰久; 岡田 隆平; 服部 夏子; 河野 辰幸; 岸本 誠司; 朝蔭 孝宏

doi:10.5981/jjhnc.43.28

The effects of transoral surgery for the recurrent hypopharyngeal cancer after radiation therapy with cetuximab

Fuminori Nomura, Taro Sugimoto, Kenro Kawada, Takuro Sumi, Yousuke Ariizumi, Yusuke Kiyokawa, Akihisa Tasaki, Ryuhei Okada, Natsuko Hattori, Tatsuyuki Kawano, Seiji Kishimoto, Takahiro Asakage

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Keywords: Hypopharyngeal cancer, Cetuximab, Salvage surgery, Endoscopic laryngopharyngeal surgery, Surgical site infection

JOURNAL FREE ACCESS

2017 Volume 43 Issue 1 Pages 28-32

DOI https://doi.org/10.5981/jjhnc.43.28

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Abstract

Objective: The aim of this study was to clarify the safety and suitability of endoscopic pharyngolaryngeal surgery （ELPS） for local recurrence after cetuximab combination radiation therapy （bio-radiation therapy: BRT）.
Materials and methods: We retrospectively evaluated by chart review the treatment results and complications for five hypopharyngeal cancer patients who underwent ELPS as salvage surgery after BRT, from April 2013 to October 2014.
Result: One of the five cases died due to local recurrence of the disease, another case remains alive with disease, and the remaining three cases have no recurrence and can take food normally. The local recurrence case had a deep part positive surgical margin according to the results of postoperative pathology. Two cases included surgical site infection, which were improved by conservative medical treatment.
Conclusion: ELPS as salvage surgery after BRT is useful for local control and larynx preservation, but it is necessary to prescribe precisely its adaptation.

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