上顎洞原発扁平上皮癌T4症例の多施設による後ろ向き観察研究

本間 明宏; 林 隆一; 松浦 一登; 加藤 健吾; 川端 一喜; 門田 伸也; 長谷川 泰久; 鬼塚 哲郎; 藤本 保志; 岩江 信法; 大上 研二; 松塚 崇; 吉野 邦俊; 藤井 正人

doi:10.5981/jjhnc.39.310

The current status of the treatment for T4 maxillary sinus cancer in Japan – a multi-institutional retrospective observation study

Akihiro Homma, Ryuichi Hayashi, Kazuto Matsuura, Kengo Kato, Kazuyoshi Kawabata, Nobuya Monden, Yasuhisa Hasegawa, Tetsuro Onitsuka, Yasushi Fujimoto, Shigemichi Iwae, Kenji Okami, Takashi Matsuzuka, Kunitoshi Yoshino, Masato Fujii

Author information

Akihiro Homma
Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine
Ryuichi Hayashi
Division of Head and Neck Surgery, National Cancer Center Hospital East
Kazuto Matsuura
Division of Head and Neck Surgery, Miyagi Cancer Center
Kengo Kato
Department of Otolaryngology-Head and Neck Surgery, Tohoku University School of Medicine
Kazuyoshi Kawabata
Department of Head and Neck Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research
Nobuya Monden
Department of Otorhinolaryngology-Head and Neck Surgery, National Shikoku Cancer Center
Yasuhisa Hasegawa
Department of Head and Neck Surgery, Aichi Cancer Center
Tetsuro Onitsuka
Department of Head and Neck Surgery, Shizuoka Cancer Center
Yasushi Fujimoto
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine
Shigemichi Iwae
Department of Head and Neck Surgery, Hyogo Cancer Center
Kenji Okami
Department of Otolaryngology, Tokai University, School of Medicine
Takashi Matsuzuka
Department of Otolaryngology, Fukushima Medical University School of Medicine
Kunitoshi Yoshino
Department of Otolaryngology, Head and Neck Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
Masato Fujii
Department of Otorhinolaryngology, National Tokyo Medical Center

Keywords: Head and neck cancer, Maxillary sinus cancer, Squamous cell carcinoma, Multi-institutional, Retrospective observation study

JOURNAL FREE ACCESS

2013 Volume 39 Issue 3 Pages 310-316

DOI https://doi.org/10.5981/jjhnc.39.310

Details

Abstract

[Purpose] To assess the current status in Japan of the treatment for squamous cell carcinoma of the T4 maxillary sinus (MS-SCC) and its use to plan clinical trials in the future.
[Patients] The data for 128 patients with previously untreated MS-SCC were obtained from 28 institutions from 2006 to 2007. Of the 128 patients, 118 patients with curative intent were included in an analysis of the treatment and its results.
[Results] Of the 118 patients, 73 patients had T4a disease, and 45 with T4b. Thirty-nine patients (33.1%) were treated with total maxillectomy, 25 (21.2%) with partial maxillectomy, 22 patients (18.6%) with RADPLAT, 19 patients (16.1%) with IV-CRT, and 13 patients (11.0%) with others. The 5-year overall survival rate and local control rate for 118 patients were 49.8% and 48.9%, respectively. The 5-year overall survival rates for patients with T4aN0M0 and T4bN0M0 were 67.5% and 29.8%, respectively.
[Conclusion] This study was retrospective, but we could understand the tendency of treatment choice and treatment results. It will be useful information to plan clinical trials in the future.

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