Between February 2009 and January 2010, 13 patients with locally advanced squamous cell carcinoma of the tongue underwent proton beam therapy combined with intra-arterial infusion chemotherapy via a superficial temporal artery. Their characteristics were as follows: median age 64 years old, 4 females and 9 males. Two patients were clinical stage III and 11 patients were clinical stage IVA. Though the follow-up period was short, the initial results of this therapy were 12 CR and 1 PR. Later, local recurrence was detected in 4 patients and neck recurrence was detected in 2 patients. The local control rate for the primary site and the neck were 69.2% (9/13) and 80.0% (2/10), respectively. In cases of local recurrence, most of them occurred from non-perfusion areas; there was no case with distant metastasis and osteoradiation necrosis of the mandibular bone and tooth during the follow-up period. These results confirm the importance of examining the perfusion area. Though the period of observation was short, proton beam therapy combined with intra-arterial infusion chemotherapy is thought to be an effective treatment for locally advanced tongue cancer, and proton therapy may also be effective for cervical lymph node metastases.